STAT1 Monoclonal Antibody
This is a STAT1 Monoclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
Signal transducer and activator of transcription that mediates signaling by interferons (IFNs) . Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state.
Synonyms
Signal transducer and activator of transcription 1 91kD, CANDF7, DKFZp686B04100, IMD31A, IMD31B, IMD31C, ISGF 3, ISGF-3, OTTHUMP00000163552, OTTHUMP00000165046, OTTHUMP00000165047, OTTHUMP00000205845, Signal transducer and activator of transcription 1 91kDa, Signal tr
Swiss Prot
P42224
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic Peptide of STAT1
Clonality
Monoclonal
Conjugation
Unconjugated
Type
Monoclonal Antibody
Applications
IHC-p
Purification Method
Protein A purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
IHC 1:100-200
Buffer
PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Host or Source
Mouse
Isotype
IgG
Available Sizes
Curated Selection
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