Glisoxepide

Glisoxepide, a sulphonamide derivative, is an orally available nonselective K (ATP) channel blocker, with antihyperglycemic activity and cardiovascular regulation effect[1][2][3].

Product Specifications

CAS Number

[25046-79-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/glisoxepide.html

Purity

95.55

Solubility

DMSO : 4.5 mg/mL (ultrasonic; warming)

Smiles

O=C(C1=NOC(C)=C1)NCCC2=CC=C(S(=O)(NC(NN3CCCCCC3)=O)=O)C=C2

Molecular Formula

C20H27N5O5S

Molecular Weight

449.52

Precautions

H302, H315, H319, H335

References & Citations

[1]Sato T, et al. Bepridil, an antiarrhythmic drug, opens mitochondrial KATP channels, blocks sarcolemmal KATP channels, and confers cardioprotection. J Pharmacol Exp Ther. 2006 Jan;316 (1) :182-8. Epub 2005 Sep 20.|[2]Selvaag E. Photohemolytic potency of oral antidiabetic drugs in vitro: effects of antioxidants and a nitrogen atmosphere. Photodermatol Photoimmunol Photomed. 1996 Aug;12 (4) :166-70.|[3]Fückel D, et al. Interaction of sulfonylureas with the transport of bile acids into hepatocytes. Eur J Pharmacol. 1992 Mar 31;213 (3) :393-404.