Amantadine-d15

Amantadine-d15 is the deuterium labeled Amantadine. Amantadine (1-Adamantanamine) is an antiviral agent with activity against influenza A viruses. Amantadine blocks the proton flow through the M2 ion channel (M2 proton channel of influenza A) and thus prevents the release of viral RNA into the cytoplasm of the infected cells. Amantadine is an antiparkinsonian agent[1][2].

Product Specifications

CAS Number

[33830-10-3]

Product Name Alternative

1-Adamantanamine-d15; 1-Aminoadamantane-d15

UNSPSC

12352211

Hazard Statement

H302, H314, H361, H412

Target

Apoptosis; Influenza Virus; Orthopoxvirus; SARS-CoV

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Apoptosis

Field of Research

Cancer; Infection; Neurological Disease

Purity

98.13

Solubility

10 mM in DMSO|DMSO : 10mg/mL (ultrasonic; adjust pH to 2 with 1M HCl)

Smiles

[2H]C1([2H])C2(C([2H])([2H])[C@@](C3([2H])[2H])([2H])C([2H])([2H])[C@]1([2H])C([2H])([2H])[C@@]3([2H])C2([2H])[2H])N

Molecular Formula

C10H2D15N

Molecular Weight

166.34

Precautions

H302, H314, H361, H412

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Suzuki H, et al. Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother. 2003;9 (3) :195-200.|[3]Hubsher G, et al. Amantadine: the journey from fighting flu to treating Parkinson disease. Neurology. 2012;78 (14) :1096-1099.