AVE 0991

AVE 0991 is a nonpeptide and orally active angiotensin- (1-7) receptor agonist with an IC50 of 21 nM[1].

Product Specifications

CAS Number

[304462-19-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Angiotensin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/AVE-0991.html

Purity

99.91

Solubility

DMSO : 41.67 mg/mL (ultrasonic)

Smiles

O=S(C1=C(C2=CC=C(CN3C(C=O)=C(OC)N=C3C4=CC=CC=C4)C=C2)C=C(CC(C)C)S1)(NC(NCC)=O)=O

Molecular Formula

C29H32N4O5S2

Molecular Weight

580.72

Precautions

H302, H315, H319, H335

References & Citations

[1]Wiemer G, et al. AVE 0991, a nonpeptide mimic of the effects of angiotensin- (1-7) on the endothelium. Hypertension. 2002 Dec;40 (6) :847-52.|[2]Pinheiro SV, et al. Nonpeptide AVE 0991 is an angiotensin- (1-7) receptor Mas agonist in the mouse kidney. Hypertension. 2004 Oct;44 (4) :490-6.|[3]Ferreira AJ, et al. The nonpeptide angiotensin- (1-7) receptor Mas agonist AVE-0991 attenuates heart failure induced by myocardial infarction. Am J Physiol Heart Circ Physiol. 2007 Feb;292 (2) :H1113-9.|[4]Mo J, et al. AVE 0991 attenuates oxidative stress and neuronal apoptosis via Mas/PKA/CREB/UCP-2 pathway after subarachnoid hemorrhage in rats. Redox Biol. 2018 Sep 28;20:75-86.