Iptacopan (hydrochloride)
Iptacopan (LNP023) hydrochloride is an effective and orally-active highly selective factor B inhibitor with an IC50 value of 10 nM and KD of 7.9 nM. Iptacopan hydrochloride exerts a proximal effect in the complement cascade reaction, preventing the destruction (hemolysis) of red blood cells in PNH and the damage of renal cells in IgAN and C3G. Iptacopan hydrochloride can be used for the study of complement-mediated diseases, particularly paroxysmal nocturnal hemoglobinuria (PNH), primary immunoglobulin A nephropathy (IgAN), and complement 3 glomerulopathy (C3G) [1][2][3].
Product Specifications
CAS Number
1646321-63-2
Product Name Alternative
LNP023 (hydrochloride)
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Complement System
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/lnp023-hydrochloride.html
Purity
99.88
Solubility
DMSO : ≥ 100 mg/mL|H2O : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(O)C1=CC=C([C@H]2N(CC3=C(OC)C=C(C)C4=C3C=CN4)CC[C@H](OCC)C2)C=C1.[H]Cl
Molecular Formula
C25H31ClN2O4
Molecular Weight
458.98
Precautions
H315, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
Frequently Asked Questions
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