SOCS1 Polyclonal Antibody

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN) -gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.

CISH 1, CISH1, Cytokine inducible SH2 protein 1, JAB, JAK binding protein, JAK-binding protein, Janus kinase binding protein, SOCS 1, SOCS-1, Socs1, SOCS1, SSI 1, SSI-1, SSI1, STAT induced STAT inhibitor 1, STAT-induced STAT inhibitor 1, Suppressor of cytokine signaling