Sertindole
Product Specifications
UNSPSC Description
Sertindole (Lu 23-174) is an orally active 5-HT2A, 5-HT2C, dopamine D2, and αl-adrenergic receptors antagonist. Sertindole shows antipsychotic activity and anti-proliferative activity to multiple cancer cells[1][2][3].
Target Antigen
5-HT Receptor; Adrenergic Receptor; Autophagy; Dopamine Receptor
Type
Reference compound
Related Pathways
Autophagy;GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Sertindole.html
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
FC1=CC=C(N2C3=CC=C(Cl)C=C3C(C4CCN(CCN5CCNC5=O)CC4)=C2)C=C1
Molecular Weight
440.94
References & Citations
[1]David Murdoch, et al. Sertindole : a review of its use in schizophrenia. CNS Drugs. 2006;20(3):233-55.|[2]Wei Zhang, et al. Antiproliferative activities of the second-generation antipsychotic drug sertindole against breast cancers with a potential application for treatment of breast-to-brain metastases. Sci Rep. 2018 Oct 25;8(1):15753.|[3]Mario F Juruena, et al. Sertindole in the management of schizophrenia. J Cent Nerv Syst Dis. 2011 May 17;3:75-85.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-14543/Sertindole-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-14543/Sertindole-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
106516-24-9
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
26122124 3 x 1.0μg DNA
KRTAP12-1 CRISPRa sgRNA lentivector (set of three targets)(Mouse)
Ask
View Details 
MBS1235311-01 0.02 mg (E-Coli)
Recombinant Bacillus pumilus UPF0234 protein BPUM_1028 (BPUM_1028)
Ask
View Details MBS1235311-02 0.1 mg (E-Coli)
Recombinant Bacillus pumilus UPF0234 protein BPUM_1028 (BPUM_1028)
Ask
View Details 
MBS1235311-03 0.02 mg (Yeast)
Recombinant Bacillus pumilus UPF0234 protein BPUM_1028 (BPUM_1028)
Ask
View Details MBS1235311-04 0.1 mg (Yeast)
Recombinant Bacillus pumilus UPF0234 protein BPUM_1028 (BPUM_1028)
Ask
View Details