DSP Polyclonal Antibody

Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus.

250/210 kDa paraneoplastic pemphigus antigen, DCWHKTA, Desmoplakin (DPI DPII), Desmoplakin, Desmoplakin I, Desmoplakin II, DESP, DP, DP I, DP II, DPI, DPII, DSP, KPPS2, PPKS 2, PPKS2