TNK2 Polyclonal Antibody

This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP) -stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.

Acetate kinase 1, Acetokinase 1, ACK 1, ACK, ACK-1, ACK1, ACK1, Activated Cdc42 associated kinase 1, Activated CDC42 kinase 1, Activated p21cdc42Hs kinase, FLJ44758, FLJ45547, p21cdc42Hs, TNK 2, TNK2, Tyrosine kinase non receptor 2, Tyrosine kinase non receptor protein 2