LZTFL1 Polyclonal Antibody

This gene encodes a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This gene may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. Alternative splicing of this gene results in multiple transcript variants.

5530402H04Rik,6130400H19Rik, AI414725, AW048545, BBS17, DKFZp686H2076, FLJ36386, Leucine zipper transcription factor like 1, Leucine zipper transcription factor like protein 1, Leucine zipper transcription factor-like protein 1, LZTFL 1, Lztfl1, Lztfl1 leucine zippe