HIF1AN Polyclonal Antibody
This is a HIF1AN Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
Factor inhibiting HIF-1 (FIH-1) exists as a homodimer and binds to HIF-1alpha. Specifically, FIH-1 operates as an asparaginyl hydroxylase. It catalyzes the hydroxylation of the beta-carbon of Asparagine residue 803 within the carboxy terminal transactivation domain of HIF-1alpha. This hydroxylation event blocks the association of HIF-1alpha with co-activators. FIH-1 also binds to von Hippel-Lindau (VHL) tumor suppressor protein, which represses transcriptional ac-tivity of HIF-1alpha. In transiently transfected human osteosarcoma cells, FIH-1 localizes to the cytoplasm.
Synonyms
DKFZp762F1811, Factor inhibiting HIF-1, Factor inhibiting HIF1, FIH 1, FIH-1, FIH1, FLJ20615, FLJ22027 , HIF1AN, HIF1N, Hypoxia inducible factor 1 alpha inhibitor, Hypoxia inducible factor 1 alpha subunit inhibitor, Hypoxia inducible factor asparagine hydroxylase, Hyp
Swiss Prot
Q9NWT6
Accession Number
NP_060372
Reactivity
Human, Mouse
Immunogen
Synthetic peptide of human HIF1AN
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IHC, ELISA
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
0.6 mg/mL
Dilution
WB 1:500-1:2000, IHC 1:50-1:300
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
40 kDa
Host or Source
Rabbit
Isotype
IgG
Available Sizes
Curated Selection
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