UHRF2 Polyclonal Antibody

This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding.

DKFZp434B0920, DKFZp686G0837, E3 ubiquitin-protein ligase UHRF2, MGC33463, Np95 like RING finger protein, Np95-like ring finger protein, Np95/ICBP90 like RING finger protein, Np95/ICBP90-like RING finger protein, Nuclear protein 97, Nuclear zinc finger protein Np9