HMGCS1 Polyclonal Antibody
This is a HMGCS1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
HMG-CoA Synthase exists as both a mitochondrial (mHMGCS) and cytoplasmic (cHMGCS) enzyme that condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The HMG-CoA produced by cHMGCS is transformed into mevalonate by HMG-CoA reductase, which starts isoprenoid biosynthesis. End products of the isoprenoid pathway include cholesterol, ubiquinone, dolichol, isopentenyl adenosine and farnesyl groups. mHMGCS, together with HMG-CoA Lyase, is responsible for ketone body biosynthesis. mHMGCS is expressed in liver and kidney. Fasting, cAMP and fatty acids increase the level of transcription of mHMGCS, while feeding and insulin repress it. A regulatory element within the mHMGCS promoter confers transcriptional regulation by PPAR, RXR, COUP-TF and HNF-4.
Synonyms
3 hydroxy 3 methylglutaryl Coenzyme A synthase 1 (soluble),3-hydroxy-3-methylglutaryl coenzyme A synthase, cytoplasmic, EC 2.3.3.10, HMCS1, HMG CoA synthase, HMG-CoA synthase, HMGCS, HMGCS1, Hydroxymethylglutaryl CoA synthase, cytoplasmic, Hydroxymethylglutaryl-CoA
Swiss Prot
Q01581
Accession Number
NP_001091742
Reactivity
Human
Immunogen
Synthetic peptide of human HMGCS1
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IHC, ELISA
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
0.4 mg/mL
Dilution
WB 1:500-1:2000, IHC 1:50-1:200
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
57 kDa
Host or Source
Rabbit
Isotype
IgG
Available Sizes
Curated Selection
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