NOD2 Polyclonal Antibody

This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs) . The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome.

ACUG, Arthrocutaneouveal granulomatosis, BLAU, CARD15, Caspase recruitment domain family, member 15, Caspase recruitment domain protein 15, Caspase recruitment domain-containing protein 15, CD, CLR16.3, IBD1, Inflammatory bowel disease protein 1, LRR containing prote