ARAP1 Polyclonal Antibody

The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3) -dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.

2410002L19Rik, ANK repeat and PH domain-containing protein 1, ARAP 1, Arap1, ARAP1, Arf GAP Rho GAP ankyrin repeat and pleckstrin homology domains containing protein 1, Arf GAP Rho GAP ankyrin repeat and pleckstrin homology domain containing protein 1, Arf-GAP