SCN11A Polyclonal Antibody

Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.

HNaN, NaN, NAV1.9, Peripheral nerve sodium channel 5, PN 5, PN5, SCN 11A, SCN 12A, Scn11a, SCN12A, SCNBA, Sensory neuron sodium channel 2, SNS 2, SNS2, Sodium channel protein type 11 subunit alpha, Sodium channel protein type XI subunit alpha, Sodium channel voltage gate