D-Mannoheptulose

D-Mannoheptulose is a 7-carbon keto sugar found in avocado. D-mannoheptulose is a specific inhibitor of D-glucose phosphorylation by hexokinase isoenzymes. D-Mannoheptulose can block insulin release and utilization of carbohydrate in rat. D-Mannoheptulose has various functions as anti-oxidants, anticancer effects and energy sources[1][2][3][4].

Product Specifications

CAS Number

[3615-44-9]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Hexokinase

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/d-mannoheptulose.html

Purity

99.90

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

OCC([C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)=O

Molecular Formula

C7H14O7

Molecular Weight

210.18

Precautions

H302, H315, H319, H335

References & Citations

[1]D-mannoheptulose and perseitol in ‘Hass’ avocado: Metabolism in seed and mesocarp tissue. South African Journal of Botany. 2012 Mar; 79:159-165.|[2]Courtois P, et al. D-mannoheptulose phosphorylation by hexokinase isoenzymes. Int J Mol Med. 2001 Apr;7 (4) :359-63.|[3]Frenkel G, et al. Metabolic effects of insulin blockade by D-mannoheptulose in the sand rat (Psammomys obesus) and the rat. Gen Comp Endocrinol. 1972 Oct;19 (2) :341-4.|[4]Al-Ziaydi, A.G. Evaluation of D-Mannoheptulose and Doxorubicin as Potential Therapeutic Agents for Breast Cancer by Targeting Glycolysis and Inducing Apoptosis. Ind J Clin Biochem (2024) .