(R) -NVS-ZP7-4
(R) -NVS-ZP7-4 is the R-isomer of NVS-ZP7-4. NVS-ZP7-4 is a Zinc transporter SLC39A7 (ZIP7) inhibitor that is also the first reported chemical tool to probe the impact of modulating ER zinc levels and investigate ZIP7 as a novel agentgable node in the Notch pathway.
Product Specifications
CAS Number
2517682-14-1
UNSPSC
12352005
Target
Others
Type
Reference compound
Related Pathways
Others
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/r-nvs-zp7-4.html
Purity
98.80
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NC12CCN(C[C@H](NC3=NC4=CC=C(F)C=C4S3)CC5=CC=CC=C5)CC2)NC6=C1C=CC=C6
Molecular Formula
C28H28FN5OS
Molecular Weight
501.62
References & Citations
[1]Nolin E, et al. Discovery of a ZIP7 inhibitor from a Notch pathway screen. Nat Chem Biol. 2019 Feb;15 (2) :179-188.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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