PIM1 Polyclonal Antibody

The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons.

Oncogene PIM 1, Oncogene PIM1, PIM 1, pim 1 kinase 44 kDa isoform, Pim 1 kinase, pim 1 oncogene (proviral integration site 1), Pim 1 oncogene, PIM, PIM1, pim1 kinase 44 kDa isoform, PIM1, Pim2, PIM3, Proto oncogene serine/threonine protein kinase Pim 1, Proto-oncogene