GDNF Polyclonal Antibody
This is a GDNF Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing.
Synonyms
Astrocyte derived trophic factor, Astrocyte derived trophic factor 1, Astrocyte-derived trophic factor, ATF 1, ATF 2, Atf, ATF1, ATF2, gdnf, GDNF, Glial cell derived neurotrophic factor, Glial Cell Line Derived Neurotrophic Factor, Glial cell line-derived neurotrophi
Swiss Prot
Q07731, P48540
Reactivity
Mouse, Rat
Immunogen
KLH conjugated Synthetic peptide corresponding to mouse GDNF
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
IHC
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
80 μg/mL
Dilution
IHC 1:100-1:500
Buffer
PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Host or Source
Rabbit
Isotype
IgG
Available Sizes
Curated Selection
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