IL10 Polyclonal Antibody
This is a IL10 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
Interleukin (IL) -10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.
Synonyms
CSIF, Cytokine synthesis inhibitory factor, GVHDS, IL 10, IL-10, IL10, IL10, IL10A, Interleukin 10, Interleukin-10, MGC126450, MGC126451, T-cell growth inhibitory factor, TGIF
Swiss Prot
P18893 , P29456
Reactivity
Mouse, Rat
Immunogen
KLH conjugated Synthetic peptide corresponding to IL-10
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
IHC, IF
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
150 μg/mL
Dilution
IHC 1:200-1:1000, IF 1:200-1:1000
Buffer
PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Host or Source
Rabbit
Isotype
IgG
Available Sizes
Curated Selection
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