BRCA2 Polyclonal Antibody
This is a BRCA2 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.
Synonyms
BRCA 2, BRCC 2, Breast and ovarian cancer susceptibility gene early onset antibody, BROVCA2, FACD, FAD 1, FANCB, GLM3
Swiss Prot
P51587
Reactivity
Human, Rat
Immunogen
Recombinant Human Breast cancer type 2 susceptibility protein
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IHC, IF
Purification Method
Antigen Affinity Purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:1000-1:3000 IHC 1:100-1:200 IF 1:100-1:400
Buffer
PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
384 kDa
Observed Molecular Weight
384 kDa
Host or Source
Rabbit
Isotype
IgG
Available Sizes
Curated Selection
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