TRIP4 Polyclonal Antibody

This gene encodes a subunit of the tetrameric nuclear activating signal cointegrator 1 (ASC-1) complex, which associates with transcriptional coactivators, nuclear receptors and basal transcription factors to facilitate nuclear receptors-mediated transcription. This protein is localized in the nucleus and contains an E1A-type zinc finger domain, which mediates interaction with transcriptional coactivators and ligand-bound nuclear receptors, such as thyroid hormone receptor and retinoid X receptor alpha, but not glucocorticoid receptor. Mutations in this gene are associated with spinal muscular atrophy with congenital bone fractures-1 (SMABF1) .

Activating signal cointegrator 1, ASC 1, ASC-1, HsT17391, Thyroid hormone receptor interactor 4, Thyroid receptor interacting protein 4, Thyroid receptor-interacting protein 4, TR-interacting protein 4, TRIP 4, TRIP-4, Trip4, TRIP4, ZC2HC5, Zinc finger C2HC5 type