AZ-33
AZ-33 (LDHA-IN-4) (compound 33) is a selective lactate dehydrogenase A (LDHA) inhibitor with an IC50 of 0.5 μM and a Kd of 0.093 μM[1].
Product Specifications
CAS Number
1370290-34-8
Product Name Alternative
LDHA-IN-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Lactate Dehydrogenase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ldha-in-4.html
Purity
98.06
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C(CC1=CC=C(CCCC(NCCC(NC2=CC3=C(N=C(C)S3)C=C2)=O)=O)C=C1)C(O)=O)O
Molecular Formula
C25H27N3O6S
Molecular Weight
497.56
Precautions
H302, H315, H319, H335
References & Citations
[1]Ward RA, et al. Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation. J Med Chem. 2012 Apr 12;55 (7) :3285-306. |[2]Granchi C, et al. Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds. Org Biomol Chem. 2013 Oct 14;11 (38) :6588-96.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
LDHA
Available Sizes
Frequently Asked Questions
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