AZ-33

AZ-33 (LDHA-IN-4) (compound 33) is a selective lactate dehydrogenase A (LDHA) inhibitor with an IC50 of 0.5 μM and a Kd of 0.093 μM[1].

Product Specifications

CAS Number

[1370290-34-8]

Product Name Alternative

LDHA-IN-4

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Lactate Dehydrogenase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ldha-in-4.html

Purity

98.06

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C(CC1=CC=C(CCCC(NCCC(NC2=CC3=C(N=C(C)S3)C=C2)=O)=O)C=C1)C(O)=O)O

Molecular Formula

C25H27N3O6S

Molecular Weight

497.56

Precautions

H302, H315, H319, H335

References & Citations

[1]Ward RA, et al. Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation. J Med Chem. 2012 Apr 12;55 (7) :3285-306. |[2]Granchi C, et al. Assessing the differential action on cancer cells of LDH-A inhibitors based on the N-hydroxyindole-2-carboxylate (NHI) and malonic (Mal) scaffolds. Org Biomol Chem. 2013 Oct 14;11 (38) :6588-96.