AF647 Anti-Mouse IL-17A Antibody
This is a AF647 Anti-Mouse IL-17A Flow Cytometry Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course.
Synonyms
Interleukin-17A, IL-17, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8, CTLA-8, CTLA8
Gene ID
16171
Swiss Prot
Q62386
Reactivity
Mouse
Clonality
Monoclonal
Conjugation
AF647
Type
Flow Cytometry Antibody
Applications
ICFC
Assay Type
Antibody
Concentration
0.5 mg/mL
Buffer
PBS with 0.05% Proclin300, 1% BSA
Storage Conditions
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
Host or Source
Rat
Isotype
Rat IgG1, κ
Available Sizes
Curated Selection
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