Necrostatin 2

Necrostatin 2 is a potent necroptosis inhibitor. EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM. Necrostatin 2 is also a RIPK1 inhibitor.

Product Specifications

CAS Number

[852391-19-6]

UNSPSC

12352005

Hazard Statement

H302+H312+H332, H315, H319, H335

Target

RIP kinase

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/necrostatin-2.html

Purity

99.92

Solubility

DMSO : ≥ 100 mg/mL

Smiles

ClC1=C2C(C(C[C@@H]3C(N(C)C(N3)=O)=O)=CN2)=CC=C1

Molecular Formula

C13H12ClN3O2

Molecular Weight

277.71

Precautions

H302+H312+H332, H315, H319, H335

References & Citations

[1]Teng X, et al. Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors. Bioorg Med Chem Lett. 2007 Dec 15;17 (24) :6836-40.|[2]Jagtap PG, et al. Structure-activity relationship study of tricyclic necroptosis inhibitors. J Med Chem. 2007 Apr 19;50 (8) :1886-95.|[3]Teng X, et al. Structure-activity relationship study of novel necroptosis inhibitors. Bioorg Med Chem Lett. 2005 Nov 15;15 (22) :5039-44.|[4]Takahashi N, et al. Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models. Cell Death Dis. 2012 Nov 29;3:e437.