ZNF451 Polyclonal Antibody
This is a ZNF451 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494) . Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro) . Required for MCM4 sumoylation (By similarity) . Has no activity with SUMO1 (PubMed:26524493) . Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493) . Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9'. Plays a role in regulating the transcription of AR targets.
Synonyms
ZNF451, COASTER, dJ417I1.1
Gene ID
26036
Swiss Prot
Q9Y4E5
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human ZNF451 (NP_001026794.1) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:200-1:2000
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
63 kDa/115 kDa/121 kDa
Observed Molecular Weight
Refer to figures
Host or Source
Rabbit
Isotype
IgG
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
