ZNF451 Polyclonal Antibody
This is a ZNF451 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins (PubMed:26524493, PubMed:26524494) . Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro) . Required for MCM4 sumoylation (By similarity) . Has no activity with SUMO1 (PubMed:26524493) . Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' (PubMed:26524493) . Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9'. Plays a role in regulating the transcription of AR targets.
Synonyms
ZNF451, COASTER, dJ417I1.1
Gene ID
26036
Swiss Prot
Q9Y4E5
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human ZNF451 (NP_001026794.1) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:200-1:2000
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
63 kDa/115 kDa/121 kDa
Observed Molecular Weight
Refer to figures
Host or Source
Rabbit
Isotype
IgG
Available Sizes
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