GRIA4 Polyclonal Antibody

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate) -sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G) . Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia.

AMPA 4, AMPA selective glutamate receptor 4, AMPA-selective glutamate receptor 4, AMPA4, GluA 4, GluA4, GluR 4, GluR D, GluR-4, GluR-D, GluR4, GLUR4C, GLURD, Glutamate receptor 4, Glutamate receptor ionotrophic AMPA 4, Glutamate receptor ionotropic, GRIA 4, Gria4, GRIA4