CREBZF Polyclonal Antibody

Host cell factor (HCF) is a cellular cofactor required for the activation of VP16 which expresses the herpes simplex virus immediate early gene. V16 binds to HCF through a 4-amino acid motif similar to the HCF binding domain of the basic leucine-zipper proteins Luman and Zhangfei (ZF) . Luman activates promoters containing cAMP or unfolded protein response elements (UPRE) . Zhangfei suppresses the transcriptional activity of Luman, but requires HCF binding which may target Luman and Zhangfei to a common location. Sequence analysis predicts that the deduced 272-amino acid Zhangfei protein has a negatively charged N terminus, a leucine zipper of 6 heptad leucine repeats separated by a conserved 6-amino acid spacer, a basic domain, and a bZIP region. It is also presumed that the N-terminal acidic region of Zhangfei is an activation domain.

1110034C16Rik,6330417B10Rik, AI225749, AI606244, CREB/ATF bZIP transcription factor, Crebzf, FLJ94018, HCF-binding transcription factor Zhangfei, Host cell factor-binding transcription factor Zhangfei, LAZip, LAZipII, SHP-interacting leucine zipper protein, SMILE, ZF