(R, S, S) -VH032

(R, S, S) -VH032 is Ligand for E3 Ligase used in the synthesis of PROTACs. VH032 is a VHL ligand and VHL/HIF-1α interaction inhibitor that recruits von Hippel-Lindau (VHL) proteins. (R, S, S) -VH032 synthesizes the tau-targeting small molecule PROTAC C004019 (HY-138669) [1].

Product Specifications

CAS Number

[2230826-33-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Ligands for E3 Ligase

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/r-s-s-vh032.html

Purity

98.99

Solubility

10 mM in DMSO

Smiles

CC1=C(SC=N1)C(C=C2)=CC=C2CNC([C@@H]3N(C[C@H](C3)O)C([C@@H](N)C(C)(C)C)=O)=O

Molecular Formula

C22H30N4O3S

Molecular Weight

430.56

Precautions

H302, H315, H319, H335

References & Citations

[1]Wang W, et al. A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models. Theranostics. 2021 Mar 11;11 (11) :5279-5295.