VRK1 Polyclonal Antibody
This is a VRK1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.
Synonyms
MGC117401, MGC138280, MGC142070, PCH1, PCH1A, Serine/threonine protein kinase VRK1, Serine/threonine-protein kinase VRK1, Vaccinia related kinase 1 , Vaccinia virus B1R related kinase 1, Vaccinia-related kinase 1, VRK1, VRK1
Swiss Prot
Q99986
Accession Number
BC113510
Reactivity
Human, Mouse
Immunogen
Fusion protein of human VRK1
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IHC, ELISA
Purification Method
Antigen affinity purification
Assay Type
Antibody
Concentration
0.5 mg/mL
Dilution
WB 1:500-1:2000, IHC 1:25-1:100, ELISA 1:5000-1:10000
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
45 kDa
Observed Molecular Weight
Refer to figures
Host or Source
Rabbit
Isotype
IgG
Available Sizes
Curated Selection
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