CBFA2T3 Polyclonal Antibody

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t (16;21) (q24; q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants.

Cbfa2t3, Ccore binding factor runt domain alpha subunit 2 translocated to 3, ETO2, hMTG16, hMTG16a, hMTG16b, MTG16, MTG16, MTG8 related gene 2, MTG8 related protein MTG16a, MTG8 related protein MTG16b, MTG8-related protein 2, MTGR2, Myeloid translocation gene 8 and 16