IC-87114

IC-87114 is a potent and selective PI3Kδ inhibitor with IC50 of 0.5 μM.

Product Specifications

CAS Number

[371242-69-2]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/IC-87114.html

Purity

99.85

Solubility

DMSO : 10 mg/mL (ultrasonic)

Smiles

O=C1N(C(CN2C3=C(C(N)=NC=N3)N=C2)=NC4=CC=CC(C)=C14)C5=C(C)C=CC=C5

Molecular Formula

C22H19N7O

Molecular Weight

397.43

Precautions

H302, H315, H319, H335

References & Citations

[1]Sadhu C, et al. Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement. J Immunol. 2003 Mar 1;170 (5) :2647-54.|[2]Zheng L, et al. Inactivation of PI3Kδ induces vascular injury and promotes aneurysm development by upregulating the AP-1/MMP-12 pathway in macrophages. Arterioscler Thromb Vasc Biol. 2015 Feb;35 (2) :368-77.|[3]El-Hashim AZ, et al. Src-dependent EGFR transactivation regulates lung inflammation via downstream signaling involving ERK1/2, PI3Kδ/Akt and NFκB induction in a murine asthma model. Sci Rep. 2017 Aug 30;7 (1) :9919.