CRACR2A Polyclonal Antibody
This is a CRACR2A Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
Ca2+-binding protein that plays a key role in store-operated Ca2+entry (SOCE) in T-cells by regulating CRAC channel activation. Acts as a cytoplasmic calcium-sensor that facilitates the clustering of ORAI1 and STIM1 at the junctional regions between the plasma membrane and the endoplasmic reticulum upon low Ca2+concentration. It thereby regulates CRAC channel activation, including translocation and clustering of ORAI1 and STIM1. Upon increase of cytoplasmic Ca2+resulting from opening of CRAC channels, dissociates from ORAI1 and STIM1, thereby destabilizing the ORAI1-STIM1 complex.
Synonyms
Calcium release-activated calcium channel regulator 2A, CRAC channel regulator 2A, CRACR2A, EF hand calcium binding domain 4B, EF hand calcium binding domain containing protein 4B, EF-hand calcium-binding domain-containing protein 4B, EFC4B, EFCAB 4B, Efcab4b, FLJ
Swiss Prot
Q9BSW2
Accession Number
BC004524
Reactivity
Human
Immunogen
Fusion protein of human CRACR2A
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
IHC, ELISA
Purification Method
Antigen affinity purification
Assay Type
Antibody
Concentration
0.84 mg/mL
Dilution
IHC 1:50-1:200, ELISA 1:5000-1:10000
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Host or Source
Rabbit
Isotype
IgG
Available Sizes
Curated Selection
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