CBFA2T2 Polyclonal Antibody
This is a CBFA2T2 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
In acute myeloid leukemia, especially in the M2 subtype, the t (8;21) (q22; q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.
Synonyms
AML1 MTG8, cbfa2t2, Core binding factor runt domain alpha subunit 2 translocated to 2, core-binding factor, runt domain, alpha subunit 2, DKFZp313F2116, EHT, ETO homolog on chromosome 20, ETO homologous on chromosome 20, MTG 8 like protein, MTG 8 related protein 1
Swiss Prot
O43439
Accession Number
BC040344
Reactivity
Human, Mouse
Immunogen
Fusion protein of human CBFA2T2
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, ELISA
Purification Method
Antigen affinity purification
Assay Type
Antibody
Concentration
1.26 mg/mL
Dilution
WB 1:1000-1:5000, ELISA 1:5000-1:10000
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
67 kDa
Observed Molecular Weight
Refer to figures
Host or Source
Rabbit
Isotype
IgG
Available Sizes
Curated Selection
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