PE/Cyanine5.5 Anti-Human CD197/CCR7 Antibody
This is a PE/Cyanine5.5 Anti-Human CD197/CCR7 Flow Cytometry Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
CCR7, also known as CD197, is a chemokine receptor that binds CCL19 and CCL21. CCR7 and its ligands link innate and adaptive immunity by affecting interactions between T cells and dendritic cells and their downstream effect. Naïve T cells enter the lymph node through high endothelial venules, which express CCL21. Dendritic cells and macrophages enter the lymph node through afferent lymphatics. The encounter of T cells and dendritic cells in the T cell zone is CCR7-dependent. In addition, during immunological surveillance, B cells recirculate between B-cell-rich compartments (follicles or B cell zones) in secondary lymphoid organs, surveying for antigen. After antigen binding, B cells move to the boundary of B and T zones to interact with T-helper cells; this B cell migration is directed by CCR7 and its ligands. CCR7-positive cancer cell expression has been associated with lymph node metastasis. Product Details
Synonyms
CMKBR7, EBI1, EVI1, CCR-7, CDw197
Gene ID
1236
Swiss Prot
P32248
Reactivity
Human
Clonality
Monoclonal
Conjugation
PE/Cyanine5.5
Type
Flow Cytometry Antibody
Applications
FC
Assay Type
Antibody
Buffer
PBS with 0.05% Proclin300, 1% BSA
Storage Conditions
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
Host or Source
Mouse
Isotype
Mouse IgG2a, κ
Available Sizes
Curated Selection
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