ZFAND5 Polyclonal Antibody

Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.

AN1-type zinc finger protein 5, ZA20D2, ZFAN5, Zfand5, ZFAND5A, zinc finger A20 domain containing 2 , Zinc finger A20 domain containing protein 2 , Zinc finger A20 domain-containing protein 2, zinc finger AN1 type domain 5, Zinc finger protein 216, ZNF216