CGAS Polyclonal Antibody
This is a CGAS Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2',5' phosphodiester linkage at the GpA step and the formation of a 3',5' phosphodiester linkage at the ApG step, producing c[G (2',5') pA (3',5') p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. cGAMP can be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173/STING-dependent manner (PubMed:26229115) .
Synonyms
C6orf150, cGAMP synthase, cGAS, CGAS, cGMP Synthase, Chromosome 6 open reading frame 150, Cyclic GMP-AMP synthase, h-cGAS, Hypothetical protein LOC115004, Mab 21 domain containing 1, Mab-21 domain-containing protein 1, MB21D1, MGC131892, MGC142166, MGC142168, OTTHUMP000
Swiss Prot
Q8N884
Accession Number
NP612450
Reactivity
Human
Immunogen
Synthetic peptide of human MB21D1
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, ELISA
Purification Method
Antigen affinity purification
Assay Type
Antibody
Concentration
0.78 mg/mL
Dilution
WB 1:500-1:2000, ELISA 1:5000-1:10000
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
59 kDa
Observed Molecular Weight
Refer to figures
Host or Source
Rabbit
Isotype
IgG
Available Sizes
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