CARD16 Polyclonal Antibody
This is a CARD16 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2.
Synonyms
CAR16, CARD only domain-containing protein 1, CARD only protein , CARD16, Caspase recruitment domain family, member 16, Caspase recruitment domain-containing protein 16, Caspase-1 dominant-negative inhibitor pseudo-ICE , Caspase-1 inhibitor COP, COP, COP1, Pseudo i
Swiss Prot
Q5EG05
Accession Number
NP001017534
Reactivity
Human
Immunogen
Synthetic peptide of human CARD16
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IHC, ELISA
Purification Method
Antigen affinity purification
Assay Type
Antibody
Concentration
1.1 mg/mL
Dilution
WB 1:500-1:2000, IHC 1:40-1:200, ELISA 1:5000-1:10000
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
23 kDa
Observed Molecular Weight
Refer to figures
Host or Source
Rabbit
Isotype
IgG
Available Sizes
Curated Selection
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