CAD Polyclonal Antibody

The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms.

Aspartate carbamoyltransferase, Aspartate transcarbamylase, CAD protein, CAD trifunctional protein, Carbamoyl phosphate synthetase 2, Carbamoyl-phosphate synthetase 2 aspartate transcarbamylase and dihydroorotase, CPSase ATCase DHOase, Dihydroorotase, Glutamine d