C14orf169 Polyclonal Antibody
This is a C14orf169 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Product Specifications
Background
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2) . Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity) . May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation.
Synonyms
60S ribosomal protein L8 histidine hydroxylase, C14orf169, Chromosome 14 open reading frame 169 , Histone lysine demethylase NO66, hsNO66, Hypothetical protein FLJ21802, Lysine-specific demethylase NO66, MAPJD, MYC associated protein with JmjC domain, NO66, NO66, Nu
Swiss Prot
Q9H6W3
Accession Number
NP078920
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide of human C14orf169
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
IHC, ELISA
Purification Method
Antigen affinity purification
Assay Type
Antibody
Concentration
0.8 mg/mL
Dilution
IHC 1:30-1:150, ELISA 1:5000-1:10000
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Host or Source
Rabbit
Isotype
IgG
Available Sizes
Curated Selection
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