SHP2-D26 isomer-1

SHP2-D26 isomer-1 is an isoform of SHP2-D26 (HY-145162) . SHP2-D26 isomer-1 cannot degrade SHP2 at 3-1000 nM. SHP2-D26 is a PROTAC SHP2 degrader. (Pink: SHP2 ligand (HY-176797) ; Blue: Isomer control of VHL Ligand 14 (HY-150803) ; Black: linker) [1][2].

Product Specifications

CAS Number

[2740582-16-3]

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

PROTACs; SHP2

Type

Reference compound

Related Pathways

PROTAC; Protein Tyrosine Kinase/RTK

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/shp2-protein-degrader-2.html

Concentration

10mM

Purity

99.76

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

ClC(C(SC1=NC=C(N2CCC(N)(CC2)C)N=C1N)=CC=C3)=C3NC(CCC(N(CC4)CCN4CCCCCCCCC(N[C@H](C(C)(C)C)C(N5[C@H](C[C@@H](C5)O)C(N[C@@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C)=O)=O)=O)=O)=O

Molecular Formula

C56H79ClN12O6S2

Molecular Weight

1115.89

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Wang M, et al. Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein. J Med Chem. 2020 Jul 23;63 (14) :7510-7528.|[2]Wang M, et al. Correction to "Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein". J Med Chem. 2021 Jan 14;64 (1) :906-908.