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Galectin-3 antagonist 1

Galectin-3 antagonist 1 (compound 15) is a potent and selective Galectin-3 (Gal-3) antagonist with Kd value of 5.3 μM. Meanwhile, Galectin-3 antagonist 1 binds to various Galectin with Kd values of 250 μM (Gal-4N), 18 μM (Gal-4C), 450 μM (Gal-8C), respectively[1].

Product Specifications

CAS Number

[2921603-03-2]

UNSPSC

12352005

Target

Galectin

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/galectin-3-antagonist-1.html

Purity

99.77

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC[C@H]1O[C@@H](OC)[C@@H](OC(C2=C([N+]([O-])=O)C=C(Cl)C=C2)=O)[C@@H](OC(C3=CC=C(C)C=C3)=O)[C@H]1O

Molecular Formula

C22H22ClNO10

Molecular Weight

495.86

References & Citations

[1]Bum-Erdene K, et al. Novel Selective Galectin-3 Antagonists Are Cytotoxic to Acute Lymphoblastic Leukemia. J Med Chem. 2022 Apr 28;65 (8) :5975-5989.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Galectin-3

Available Sizes

Curated Selection

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