DR6 (phospho-Ser562) rabbit pAb
This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013],
Product Specifications
Background
Synonyms
Tumor necrosis factor receptor superfamily member 21 (Death receptor 6) (CD antigen CD358)
Gene ID
27242
UniProt
O75509
Cellular Locus
Cell membrane ; Single-pass type I membrane protein.
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized phosho peptide around human DR6 (Ser562)
Clonality
Polyclonal
Isotype
IgG
Source
Rabbit
Applications
WB
Validated Applications
WB
Stability
-20°C/1 year
Concentration
1 mg/mL
Dilution
WB 1:1000-2000
Molecular Weight
72kD
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.elkbiotech.com/upload/file/Antibodies/pAb/ES16898-1.pdf
Observed Molecular Weight
72 kD
Subcellular Location
Cell membrane ; Single-pass type I membrane protein .
Other Product Names
Tumor necrosis factor receptor superfamily member 21 (Death receptor 6) (CD antigen CD358)
Gene ID (Human)
27242
SwissProt (Human)
O75509
Available Sizes
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