Purified Anti-Mouse CD120b Antibody

CD120b is a 75 kD type I transmembrane protein, also known as Tumor Necrosis Factor Receptor Type II (TNFRII) or p75. It is expressed on a variety of cells at low levels; the expression is upregulated upon activation. This receptor binds both TNF-α and LT-α (also known as TNF-β) . In association with TRAF1 and TRAF2, the receptor crosslinking induced by TNF-α or LT-α trimers is critical for signal transduction, leading to apoptosis, NF-kB activation, increased expression of proinflammatory genes, tumor necrosis, and cell differentiation depending on cell type and differentiation state.

Tumor necrosis factor receptor superfamily member 1B, Tnfrsf1b, Tumor necrosis factor receptor 2, TNF-R2, TNF-RII, TNFR-II, p75, p80 TNF-alpha receptor, CD120b