CMCoFx1

CMCoFx1 is a potent and selective cyclic peptide inhibitor of FXIIa, with high binding affinity (KD: 900 pM) and inhibitory activity (Ki: 370 pM) . It effectively blocks the intrinsic coagulation pathway in vitro, shows high serum stability, and is non-cytotoxic, making it a valuable research tool for studying thrombosis and contact activation.