RFRP-3, mouse

This peptide is the murine ortholog of avian GnIH, acting as an agonist at the GPR147 receptor. It suppresses progesterone production by downregulating FSHR and steroidogenic enzymes, while also promoting apoptosis via p53 and inhibiting ERK signaling. It is a valuable tool for studying reproductive neuroendocrinology and ovarian follicle dynamics in both in vitro and in vivo models.