CDK1/Cyc B-IN-1

CDK1/Cyc B-IN-1 (Compound 5) is a selective CDK1/Cyc B complex inhibitor with an IC50 of 97 nM. CDK1/Cyc B-IN-1 triggers apoptosis and G2/M cell cycle arrest. CDK1/Cyc B-IN-1 shows broad-spectrum cytotoxic action against cancer cell lines[1].

Product Specifications

CAS Number

[2459916-56-2]

UNSPSC

12352005

Target

Apoptosis; CDK

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cdk1-cyc-b-in-1.html

Purity

98.47

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=CC=C(C(OC)=C1)N2C(SC3=C2N=C(N=C3Cl)C)=S

Molecular Formula

C14H12ClN3O2S2

Molecular Weight

353.85

References & Citations

[1]Mohamed SH, et al. An investigative study of antitumor properties of a novel thiazolo[4,5-d]pyrimidine small molecule revealing superior antitumor activity with CDK1 selectivity and potent pro-apoptotic properties. Bioorg Med Chem. 2020 Sep 1;28 (17) :115633.